The defender has been struggling with an ankle ligament problem, and his Danish boss is concerned ahead of next month's international break.
"I'm a little worried, but the problem with Ashley is he's an international," BBC Sport quotes Laudrup as saying. "We have to be careful, but I mean the national team as well.
"I would never ask a player to step down, not to play with his country but I think it's important in combination, club and national team, that we find a solution that can benefit all of us. There will be a moment I think where Ashley will need two weeks without a game."
Williams could be absent for this weekend's Premier League clash against Arsenal.