The Welsh club goes into the game at the Liberty Stadium having lost their last three fixtures in all competitions. The Swans have also failed to score a goal in that time.
"The next game is always important, but this time that really is the case," Laudrup told the South Wales Evening Post. "I think there are three or four games during a season which are more important than normal important games, and I think the first one for us is on Saturday.
"It's one of the three or four you have in every season where you say 'Guys, it's this one we need to win because it will give us so much'."
Swansea are currently 11th in the Premier League table, while Reading occupy 19th place.