Now from one extreme to another, as Conference playoff hopefuls Kidderminster travel to the Stadium of Light on the back of scalps over Newport County and Peterborough United in the earlier stages.
With many of his first-team regulars having played 120 minutes at Old Trafford on Wednesday, Poyet is expected to heavily rotate his squad for the visit of the Midlands minnows. New Argentine signings Oscar Ustari and Santiago Vergini are expected to make their debuts in goal and defence respectively.
Liverpool loanee Fabio Borini is eligible to play and he and Lee Cattermole could be the only players retained from the starting XI that faced the Red Devils. Emanuele Giaccherini, Valentin Roberge and Andrea Dossena are among those that will probably be considered for recalls.
Kidderminster are 9-1 with leading bookmaker SkyBet to pull off another upset and new Harriers boss Andy Thorn, who has only been in charge for two weeks, is likely to keep faith with the side that came this far under Steve Burr, who was sacked with the club sixth in the table in January.
Michael Gash has scored in his last two matches, including the win over Posh in the third-round replay, and is a name to watch out for, but Thorn will be without in-form striker Joe Lolley, who scored 11 times for Kidderminster this season before moving to Championship outfit Huddersfield last week.
Possible starting lineups
Sunderland: Ustari; Celustka, Roberge, Vergini, Dossena; Larsson, Gardner, Cattermole, Giaccherini; Borini, Altidore
Kidderminster: Lewis; Vaughan, Demetriou, Jackman, Gowling; Byrne, Storer, Fowler, Johnson; Gash, Malbon
Sports Mole says: 3-1