Adebayor will miss the match due to the conditions of his loan move from Manchester City and Defoe is expected to be named as his replacement.
Redknapp said: "Jermain has been bursting for a chance to get back in and play so he has got the opportunity now.
"We have to play good football in to them, though. We can't be hitting long forward balls up to Defoe expecting him to win challenges with their central defenders."
Spurs are currently five points behind league leaders City.