The former Southampton manager, who saw his side edge past West Ham United 1-0 last week, is looking forward to his first game at White Hart Lane.
The Argentine told reporters: "I am looking forward to it. We are looking forward to it, my first official game at White Hart Lane in front of our supporters.
"We watch a lot of games from them and the last game they played well but in football not always when you play well, you win. But, yes, it is a derby, we expect a very, very tough game."
The London derby will see QPR manager Harry Redknapp visit his former club after returning the R's to the Premier League.