Spurs face West Ham United tomorrow night before hosting North London rivals Arsenal at White Hart Lane on Sunday.
Holtby believes that claiming a positive result in both matches is vital to his side's hopes of winning a Champions League spot.
He told the club's official website: "I can't wait and we've two massive games in a row now, West Ham and Arsenal.
"It doesn't get better than that. I'm already buzzing for those games. Everyone was so chuffed, delighted for all the hard work we put in [against Lyon] and I think we deserved it over the 90 minutes.
"It was great to see the lads so happy and we now go with a good feeling to West Ham on Monday, another huge game. It's an important game for everyone, for the fans, for West Ham, for us, sitting in fourth spot and trying reach third, it's a vital game."
Spurs will go above Chelsea into third place in the table if they beat West Ham tomorrow.