Villas-Boas has given Defoe a new lease of life at White Hart Lane after he endured a frustrating campaign under previous boss Harry Redknapp.
Defoe thinks that the attention to detail of the Portuguese coach has helped him make a strong start as Spurs manager.
He told The Sun: "What I like about him is every game has a different approach.
"You know exactly how we've got to play when we've got the ball and not got the ball.
"Every player knows their jobs and if you speak to any of the boys, he has been fantastic."
Villas-Boas goes in search of a fifth successive Premier League win this weekend against his former club Chelsea.