The Spurs players were booed off the pitch on Sunday after they were beaten 2-1 by Newcastle United at White Hart Lane in the Premier League.
Their League Cup campaign got off to a typically shaky start last month as they had to come from behind to earn a 3-1 victory on home turf against Nottingham Forest.
However, standing between them and a place in the fifth round will be a Brighton side that is on a woeful run of form, winning once in their last 11 games in all competitions.
The Seagulls, who are sitting a mere two points above the relegation zone in the Championship standings, earned victories over Cheltenham Town, Swindon Town and Burton Albion to reach this stage of the competition.
Possible starting lineups
Spurs: Lloris; Davies, Kaboul, Chiriches, Rose; Dembele, Mason; Lennon, Eriksen, Lamela; Soldado
Brighton: Stockdale; Calderon, Greer, Dunk, Bennett; Ince, Forster-Caskey, Gardner; Baldock, Colunga, O'Grady
Sports Mole says: 3-0