Leeds have already knocked Premier League sides such as Southampton and Everton out of the League Cup this season, and three years ago beat Manchester United at Old Trafford in this competition.
However, they drew Spurs in the next round of the cup that year and lost 3-1 in the replay.
The hosts go into the match on the back of just one defeat in their last five matches in all competitions, although poor league form has seen them drop to 11th in the Championship table.
Spurs, meanwhile, have lost just one of their last 14 matches, including a 1-1 draw with Manchester United in their last outing.
Possible starting lineups
Leeds: Kenny; Pearce, Peltier, Lees, Drury; Bryam, Brown, White, Austin; Diouf, McCormack
Tottenham: Friedel; Walker, Caulker, Dawson, Vertonghen; Lennon, Huddlestone, Dempsey, Dembele, Bale; Defoe
Sports Mole says: 1-3