Hugo Lloris starts in goal, while Jan Vertonghen is partnered by Michael Dawson in the centre of defence.
Youngster Tom Carroll will begin in a midfield that includes Gareth Bale, Aaron Lennon and Tom Huddlestone.
Spurs: Lloris; Walker, Vertonghen, Dawson, Naughton; Lennon, Huddlestone, Carroll, Bale; Adebayor, Defoe
Subs: Cudicini, Gallas, Mason, Dempsey, Sigurdsson, Falque, Livermore
Maribor: Handanovic; Milec, Rajcevic, Arghus, Mejac; Cvijanovic, Mertelj, Filipovic, Ibraimi; Tavares, Beric
Subs: Pridigar, Vidovic, Mezga, Komazec, Potokar, Viler, Dodlek