The last time the two sides met in Italy was in the group stages of the Champions League in October 2010, when Inter recorded a 4-3 win despite a hat-trick from Welsh winger Bale.
Both teams enter the match on the back of defeats, however, with Inter losing 1-0 at home to Bologna at the weekend, while Spurs' unbeaten run in the Premier League came to an end with a 3-2 loss to Liverpool.
Inter's disappointing league campaign has left them in fifth position in the Serie A table, but they are just four points behind third-placed AC Milan.
Spurs, meanwhile, sit third in the Premier League table, seven points ahead of fifth-placed Arsenal with nine matches remaining.
Inter: Carrizo; Zanetti, Juan, Chivu, Ranocchia; Stankovic, Cambiasso, Guarin, Gargano; Palacio, Cassano
Tottenham: Friedel; Walker, Gallas, Dawson, Assou-Ekotto; Parker, Dembele, Livermore; Lennon, Defoe, Sigurdsson
Sports Mole says: 2-2