Spurs will host the Swiss champions at White Hart Lane in the first leg of their last-eight encounter.
"When it comes to the quality of the individuals, we have to admit that we have the superior players," Villas-Boas is quoted as saying by Goal.com.
"But on the other hand the experience that Basel have - the fact that they have played Champions League, the fact that they are regular trophy winners, their recent European experience - also makes them one of the favourites.
"They put out Zenit [St Petersburg], which was a very strong team, and we expect a tough game."
Tottenham will be without Jermain Defoe for the game after the striker was ruled out with a muscular injury.