The Spanish coach made several changes to his side for the 10-0 win over Tahiti and is expected to alter his side again.
Spain are expected to revert to the side that beat Uruguay, although Del Bosque did confirm that Victor Valdes will start in goal.
The 62-year-old admitted that he saw the number of options at his disposal as an opportunity decide on certain players.
"Well, there will be few changes with the last match, of course. For example, Victor Valdes will be the goalkeeper," Del Bosque told reporters.
"A part from that, the rest of the players will be more or less like in the first match, but we have a lot of alternatives and possibilities.
"In one hand that is a problem for us, but in the other hand is also an opportunity to be able to choose between that many players."
Spain will face Italy in the semi-finals should they finish top of Group B.