Southampton manager Nigel Adkins has made two changes from the side that lost 3-2 at Manchester City last weekend.
Goalscoring duo Steven Davis and Rickie Lambert come into the starting XI in place of Jason Puncheon and 17-year-old James Ward-Prowse.
Meanwhile, Wigan Athletic boss Roberto Martinez makes just one alteration from the team that lost 2-0 to Chelsea.
Arouna Kone replaces Victor Moses, who completed his £9m move to Stamford Bridge yesterday.
Southampton: K. Davis, Clyne, Fonte, Hooiveld, Fox, S. Davis, Schneiderlin, Lallana, Guly, Lambert, Rodriguez
Subs: Gazzaniga, Sharp, Ward-Prowse, Richardson, Shaw, Seaborne, Puncheon
Wigan: Al Habsi, Kone, Alcaraz, McCarthy, Caldwell, Di Santo, Maloney, McArthur, Boyce, Ramis, Figueroa
Subs: Pollitt, Jones, Crusat, Watson, Gomez, Boselli, Beausejour
