West Ham were also beaten in their final match before the international break, when Stoke City left Upton Park with a 1-0 victory.
Southampton manager Mauricio Pochettino has no new injury concerns ahead of the match at St Mary's. England striker Rickie Lambert could make his 200th appearance for the club if he is selected to play.
West Ham United: WDL
Possible starting lineups
Southampton: Boruc; Chambers, Fonte, Lovren, Fox; Wanyama, Schneiderlin, Ward-Prowse, Lallana; Osvaldo, Lambert
West Ham United: Jaaskelainen; Demel, O'Brien, Collins, Reid; Noble, Diame, Nolan, Taylor, Jarvis; Maiga
Sports Mole says: 1-1