Ronald Koeman's first game in English football ended in defeat as the Saints held their own for long stages before losing 2-1 to a Liverpool side who are largely responsible for their summer exodus.
The South Coast club has again promised that Morgan Schneiderlin will not be following a quintet of other high-profile players out of the door, despite former boss Mauricio Pochettino retaining an interest in bringing him to Tottenham Hotspur.
Irvine will be keen to slot free agent signing Joleon Lescott into his defence, but the former England international, along with Gareth McAuley, is an injury doubt and therefore Craig Dawson may continue.
Costa Rica's World Cup star Cristian Gamboa has only recently linked up with the West Midlands club and may not feature, while James Morrison will also be absent from what should be an unchanged midfield.
A Saints debut for Romanian centre-back Florin Gardos, who joined from Steaua Bucuresti last week, is still a fortnight away, while Jay Rodriguez is likely to be sidelined until at least Christmas.
With his options limited, Koeman could name the same XI that he did against Liverpool, although £12m striker Shane Long could be handed a start against the team that sold him to Hull City six months ago.
Southampton won both of their fixtures against Albion last season by a 1-0 scoreline.