The hosts were by far the better side in the first half, taking the lead through Sadio Mane's strike shortly after the half-hour mark, before pushing for a second.
They were unable to double their advantage, however, and a much-improved Stoke side looked to hit back following the interval, but they could not find a way through as the Saints held out for all three points.
You can see how the game unfolded with Sports Mole's live text coverage below.
SOUTHAMPTON STARTING XI: Forster, Clyne, Fonte, Alderweireld, Bertrand, Cork, Schneiderlin, S. Davis, Mané, Tadic, Pelle
STOKE CITY STARTING XI: Begovic, Bardsley, Shawcross, Wilson, Pieters, Cameron, Nzonzi, Walters, Adam, Moses, Crouch
SOUTHAMPTON SUBSTITUTES: K. Davis, Yoshida, Gardos, Long, Wanyama, Mayuka, Reed
STOKE CITY SUBSTITUTES: Sorensen, Huth, Arnautovic, Diouf, Sidwell, Assaidi, Bojan
"We need a fast player and we know Sadio Mane is very good one against one. That's the reason. I think we have to win the battle in the midfield because I think that's the key today. We know their qualities. First of all we must have a better start because we play at home. We like to dominate from the beginning."
Southampton are by far the best team we have played this season - in my view of course! #scfc— Stoke City FC (@stokecity) October 25, 2014