The home side are unbeaten in three games, but are yet to win a game this season.
Following their opening day win, Championship new boys Yeovil have lost their last four matches.
Despite narrowly losing their last match 1-0 to Reading, Gary Johnson has kept faith with the same starting XI from a fortnight ago.
Sheffield Wednesday: Kirkland; Spence, Llera, Zayatte, Reda Johnson; Palmer, Prutton, Coke, Helan; Antonio; Nuhiu
Yeovil Town: Hennessy; Ayling, McAllister, Webster, Seaborne; Edwards, Upson, Ralls, Grant; Williams, Hayter