The Owls produced something of a surprise result in their opening match of the campaign last weekend, beating Brighton & Hove Albion 1-0 at the Amex Stadium in what was Sami Hyypia's first game in charge of the Seagulls.
Things don't get any easier for Stuart Gray's side as they take on a Derby side tipped for automatic promotion next, but he will have taken huge confidence from how his side have started the 2014-15 campaign.
Wednesday made it two wins from two on Tuesday with a commanding victory over Notts County in the League Cup, keeping a second clean sheet in the process.
For a team that made such a poor start last season, amassing a decent number of points in the early stages this time around could enable them to push on and challenge for a top-half finish.
One player who will not be involved is Dejan Kelhar, however, after the new signing was ruled out for most of the season with a knee injury.
Derby have also made a promising start to the season as they look to get over the heartbreak of having missed out on promotion to the Premier League in the dying stages of the playoff final last term.
It may not have been the most convincing of victories for a team that is expected to be challenging at the top of the table, but an early three points on the board will certainly please manager Steve McClaren.
The boss wasn't happy with his side in midweek, however, despite progressing into the second round of the League Cup with a 2-0 win over Carlisle United.
The Rams squandered a number of good chances throughout the match before finally sealing the victory in the 93rd minute through Chris Martin.
Sheff Weds: WDLDWW
Possible starting lineups
Sheff Weds: Westwood; Palmer, Lees, Loovens, Mattock; Maguire, Coke, Hutchinson, Maghoma; Lee; May
Derby: Grant; Christie, Keogh, Buxton, Forsyth; Bryson, Hughes, Hendrick; Dawkins, Martin, Russell
Sports Mole says: 1-2