"It is a fixture the fans will remember for a number of years and it is a chance to make yourself a legend," PA Sport quotes the 25-year-old as saying. "I still hold the fixture in high esteem. I was so excited when I heard the fixture was coming up and I'm hopefully playing.
"It is the biggest game for Scotland in a number of years even though it is deemed a friendly. We don't see it as a friendly and the fans won't see it as a friendly and we will be looking to win the match.
"The Tartan Army will be out in force. I think they have bought around 24,000 tickets and I'm sure there will be more down here. They are a great support and they will get right behind us and we want to do it for them."
McArthur went on to reminisce about Scotland's 1-0 victory over England in the second leg of their Euro 2000 playoff, when Don Hutchison scored the winner at Wembley.
"When you look at Don Hutchison scoring the winner, it is one of those games you remember as a kid and all through your life," he added.
"I was on the bus coming back from one of my [youth] games but I was celebrating on the bus. Hopefully we can do that on Wednesday night, give some kids memories for the rest of their lives."
Scotland's victory over England was not enough to overturn a 2-0 deficit from the first leg at Hampden Park.