Maxi Lopez's first-half goal gave the Blucerchiati a 1-0 win at the Stadio Luigi Ferraris on Monday evening, and Mihajlovic is pleased that they opened up an eight-point gap on the league's bottom three clubs.
"After the disappointment of the previous game, it was important to win," he told reporters.
"Beyond the fact that this was a derby, but because we are now eight points above the relegation zone.
"But now we are thinking towards a delicate game against Cagliari."
Sampdoria are currently 13th in the Serie A table.