The Latics currently sit two points behind their opponents in the standings after one win and two draws from their opening three games.
Meanwhile, the hosts can all but book their place in the next round of the competition with a win.
A Nick Powell strike earned Wigan a 1-1 draw when the teams faced each other at the DW Stadium two weeks ago.
Possible starting lineups
Rubin: Ryzhikov; Kuzmin, Kverkvelia, Navas, Mavinga; Mubarak, Natcho, M'Vila, Karadeniz; Ryazantsev; Mukhametshin
Wigan: Nicholls; Boyce, Barnett, Shotton, Perch; Gomez, Watson, McCann, Powell; Fortune, McManaman
Sports Mole says: 1-0