Such a strong start will have given Wolves huge confidence for the rest of the season, especially considering that they have been tipped by many to challenge for the playoffs despite their recent promotion.
However, that confidence could well be in tatters following a midweek defeat to League Two side Northampton Town, who edged to a 3-2 victory at Molineux to knock Wolves out of the League Cup.
Even so, the Midlands outfit will be eyeing Saturday's match as a winnable encounter against a team that joined them in going up from the third tier last season.
Unlike Wolves, Rotherham are expected to be in amongst the relegation candidates this season, although there were promising signs for them on the opening weekend.
It was certainly a tough start to the campaign for the newly-promoted side, and Steve Evans was happy with his team's application despite the end result.
A repeat performance in front of their first home league crowd of the season could well be enough for them to get something out of the match this time around, although fatigue could play a part following their midweek exploits.
Evans saw his side taken all the way to extra time in their League Cup first-round match against Fleetwood Town before Matt Derbyshire's penalty in the 109th minute sealed victory for the Championship side.
Rotherham picked up no new injuries over the 120 minutes and could name an unchanged side to the one that pushed Derby so close last weekend.
One thing this fixture did promise last season was goals, with the two teams sharing a staggering 16 in their two league meetings.
Possible starting lineups
Rotherham: Collin; Broadfoot, Morgan, Arnason, Skarz; Agard, Frecklington, Green, Pringle; Revell, Derbyshire
Wolves: Ikeme; Doherty, Batth, Stearman, Golbourne; Evans, McDonald, Van La Parra, Edwards, Sako; Dicko
Sports Mole says: 1-2