Juventus have dominated Serie A during the last three seasons, but Rudi Garcia's men have hinted that they have the tools to put up a significant challenge for the title this time around.
Meanwhile, suspension means that Cesena will be without goalkeeper Nicola Leali following his red card last time out against Inter Milan.
The away side have not won an encounter since the opening day of the season, which stretches back seven winless matches.
Possible starting lineups
Roma: De Sanctis; Cole, Yanga-Mbiwa, Astori, Torosidis; De Rossi, Nainggolan, Iturbe, Pjanic, Totti; Gervinho
Cesena: Agliardi; Capelli, Lucchini, Volta, Renzetti; Cascione, De Feudis, Giorgi, Duric, Marilungo; Almeida
Sports Mole says: 2-0