The Giallorossi are second in the Serie A table and are currently 19 points ahead of Milan going into their game at the San Siro.
"Everyone knows Milan have players of a high level and you can't qualify from the Champions League group phase without a strong side," he told reporters.
"We know that playing away to Milan is more difficult, but we will take our usual approach. We are going to Milan in order to win. It will be tough, but that is our ambition.
"We're a long way from the end of the season and won't think about what Juventus or any of the others are doing, so we focus only on our own results. We are ready after a great performance against Fiorentina and a good result at San Siro would be a further step forward."
Roma are yet to lose in the league this season, having won 11 and drawn four of their first 15 fixtures.