Valladolid are seen as the underdogs ahead of the clash at La Rosaleda and Djukic has revealed that he is wary of the home side's "brilliant combination play".
"If you leave them to dominate you, they will win for sure," he told Marca.
"Therefore, we have to try and play our own game, with possession, so that they suffer.
"They are a Champions League team and a fashionable team right now that can make things very difficult for us with their brilliant combination play."
Valladolid are currently eighth in La Liga, with 10 points from the first seven games.