The Castile and Leon side, who currently sit 18th, need to beat 17th-place Granada to stand a chance of moving out of the relegation zone in Spain's top flight and even then they will have to rely on other teams slipping up.
"After the match against Betis we were all devastated," he told reporters at a press conference.
"But there is no point in us looking back. Now is the time to look forward to this match with confidence and intent. I am absolutely convinced that we will stay up. To achieve that, we will count on the support of our fans, we have already demonstrated that we are a very capable team at Zorilla.
"It will be more of a dramatic match than a tactical one, as it usually is in a situation like this. We are going to go for them from the first minute. Not everything about this season will be negative, I am sure that Real Betis and Rayo Vallecano will do their job."
Osasuna, Getafe, Almeria are also in the relegation picture in La Liga.