Los Blancos are 16 points well off the pace in La Liga, and have been in turmoil recently.
The Spanish number one fractured a bone in his hand during last weekend's defeat, so he will be watching from the sidelines.
Los Rojiblancos have no new injury concerns, as Piotr Trochowski has been missing since September.
They have won their last two games and are five points off a spot in the Europa League.
Real Madrid: LWDWWL
Real Madrid: Lopez; Arbeloa, Marcelo, Pepe, Ramos; Alonso, Khedira, Di Maria, Ozil; Ronaldo; Benzema
Sevilla: Beto; Navarro, Spahic, Fazio, Cicinho; Reyes, Rakitic, Medel, Kondogbia, Navas; Negredo
Sports Mole says: 2-0