Los Blancos lost more ground on leaders Barcelona last weekend as they lost 2-1 to their arch rivals at the Camp Nou.
Meanwhile, a second consecutive victory for Sevilla could see the visitors move into the top half of the standings.
Madrid, who are still without Xabi Alonso, have no fresh injury concerns ahead of the match.
Madrid: Lopez; Ramos, Pepe, Varane, Marcelo; Khedira, Modric, Isco; Bale, Benzema, Ronaldo
Sevilla: Beto; Figueiras, Carrico, Pareja, Moreno; Jairo, Cristoforo, Rakitic, Vitolo; Bacca, Gameiro
Sports Mole says: 3-0