Atletico's triumph in La Liga last season will live long in the memory for many football fans, but it was Real who ended the campaign on a high by beating their neighbours in the Champions League final.
These two sides have already met twice this season, with Atletico picking up more silverware thanks to a 2-1 aggregate success in the Spanish Super Cup, but this is the clash that both sets of supporters have been waiting for since the fixtures were released.
Atletico boss Diego Simeone continues his touchline ban on Saturday, and he could be forced to select a squad without Cristian Rodriguez, who picked up a calf injury while on international duty with Uruguay.
Real Madrid: WL
Atletico Madrid: DW
Possible starting lineups
Real Madrid: Casillas, Arbeloa, Pepe, Ramos, Marcelo, Kroos, Modric, Rodriguez, Bale, Ronaldo, Benzema
Atletico Madrid: Moya, Juanfran, Miranda, Godin, Siqueira, Suarez, Gabi, Koke, Griezmann, Mandzukic, Garcia
Sports Mole says: 2-1