Los Blancos are in a formidable form in the league, having lost their last game back in mid-September and winning their last four.
Madrid have also not lost at home in La Liga this season, and have conceded just two goals in five matches.
On the other hand, Bilbao are just four points above the relegation zone in 12th and have lost three of their five league matches away from home.
Marcelo Bielsa's side have struggled both on the pitch and off it, and the Basque giants will be keen to kickstart their campaign with a win against their most bitter rivals.
Madrid forward Cristiano Ronaldo returned to training on Thursday after recovering from an eye injury and is likely to start against Bilbao.
Real Madrid: WWWDW
Athletic Bilbao: LDWLW
Possible starting lineups:
Real Madrid: Casillas, Arbeloa, Pepe, Ramos, Coentrao, Essien, Alonso, Callejon, Ozil, Di Maria, Ronaldo
Athletic Bilbao: Iraizoz, Iraola, Gurpegui, Amorebieta, Aurtenetxe, Perez, Iturraspe, Martinez, Susaeta, Muniaín, Aduriz
Sports Mole says: 2-1