The clash on October 26 could mark the forward's official debut for the Catalan outfit, with his four-month biting ban due to end before the Clasico.
"My debut against Madrid? It's still a long time. I don't think fitness will be an issue, but there's always the matter of adapting to the team," he told reporters at a press conference.
"But I don't think there will be a problem if I'm physically alright."
Suarez has recently been cleared to train and represent Barca in friendly matches.