The Valencia boss, whose side make the trip to the Santiago Bernabeu tonight, insists that the club must prioritise stopping the former Manchester United man in order to get a result and maintain their grip on third place.
"[Cristiano] has scored 35 goals," he said. "Keeping a hold on him has to be one of our targets. We have to be optimistic.
"We said that third place was not going to be a simple achievement, but we believe we have the strength to remain there and not be scared if we lose it in a given moment."
Meanwhile, Valencia have progressed to the semi-finals of the Europa League after beating AZ Alkmaar earlier this week.