As it stands, Barca sit in third position in La Liga, four points behind Madrid ahead of the Clasico at the Bernabeu tomorrow evening.
"This Clasico is going to be my last game in Bernabeu as a Barcelona player," the 32-year-old told reporters at a press conference.
"I have a high respect for that stadium. It is an amazing place to play in because the fans give a lot of support to Real Madrid - especially in the Clasicos - and that makes playing there very special, even if you are on the other side.
"I would like to be able to say in a few days that we won because we really need those three points if we want to dispute the title against Real Madrid."
Valdes will depart the Camp Nou on a free transfer in the summer.