Madrid welcome Barca to the Bernabeu on Sunday evening currently holding a four-point lead over the defending champions with just 10 games remaining.
"They talk of a crisis at Barca but they're in the Copa del Rey final, the quarter-finals of the Champions League and they're just four points off the lead in La Liga," Ramos told AS.
"What has changed at Barca is that fear teams had. It would be a major blow to the table if we win. The Clasico is different, it's a global and historic rivalry."
The reverse match earlier this season ended in a 2-1 Barcelona win at the Camp Nou.