It was an encounter that had footballers past and present sharing their views on Twitter.
Below, Sports Mole has picked out some of the best reaction to the seven-goal contest.
Messi with Hat tricks back to back like Kappa !!! #ElClassico— Rio Ferdinand (@rioferdy5) March 23, 2014
"I can't believe there is someone out there who has been sent off more times than me!!!!!! #sergioramos."
Former Birmingham City defender Darren Purse
"2.2 half time ElClassico. Both teams as dangerous. 2 totally different styles. Which one is the answer?? More than 1 way to skin a cat."
Manchester United midfielder Michael Carrick
"Great great game of football. So happy that Barca came away with the 3 points. Barcelona remained composed throughout. #ElClasico 3-4."
Former Arsenal and Tottenham Hotspur winger Rohan Ricketts
Messi will get all the headlines tonight but Andres Iniesta was outstanding as was Xavi. #itsaballnotabomb— Joseph Barton (@Joey7Barton) March 23, 2014
"Bale / Di Maria and Ronaldo counter attacking and WIDE play is devastating!!"
Former Manchester United defender Gary Neville
"Cracking game even if it got a bit tetchy near the end! #ElClasico."
Former Norwich City attacker Darren Huckerby
"What a poor season so far for Messi just the 34 goals!! Needs to kick on!"
Former Wales international Iwan Roberts