The majority of bookmakers are offering odds of 125/1 that Galatasaray manage to advance to the semi-finals of the Champions League at the expense of Real Madrid - such is the size of the task that lies ahead of them.
Despite the fact that the tie looks to be over, coach Jose Mourinho has been tipped to start with a strong team in Istanbul.
However, he will have to make do without the services of Xabi Alonso and Sergio Ramos because of suspension. The absence of the Spanish duo is likely to see both Raphael Varane and Michael Essien handed starting roles.
Meanwhile, the hosting Turks have their own suspension issues in the form of key striker Burak Yilmaz, who has picked up a ban.
Real Madrid: WWWWDW
Possible starting lineups
Galatasaray: Muslera; Eboue, Kaya, Nounkeu; Sneijder, Altıntop, Melo, Riera, Inan; Drogba, Bulut
Real Madrid: Lopez; Arbeloa, Varane, Pepe, Coentrao; Khedira, Essien; Modric, Ozil, Ronaldo; Benzema
Sports Mole says: 1-1