Ajax, who have four European cups to their name, will be looking to make it third time lucky in the Champions League Group D clash, having lost against Madrid in the past two seasons.
The Dutch outfit lost their opening match of the campaign to Borussia Dortmund, but have identified their home matches as paramount to their success.
Madrid, meanwhile, got off to a slow start in La Liga, but they have won their last two matches and also overcame Manchester City on matchday one of the campaign.
The Spanish outfit have also beaten the 31-time Dutch champions in five of their last 10 encounters.
Real Madrid: WLWWW
Ajax: Vermeer; Van Rhijn, Alderweireld, Moisander, Blind; De Jong, Poulsen, Eriksen; Sana, Babel, Boerrigter
Real Madrid: Casillas; Ramos, Varane, Pepe, Marcelo; Alonso, Modric; Di Maria, Ozil, Ronaldo; Higuain
Sports Mole says: 1-3