Madrid will face Borussia Dortmund in the semi-finals, while their Spanish rivals Barca will confront Bayern Munich for a place in the final.
"Everybody wants a final between Barcelona and Real Madrid," Goal.com quotes Del Bosque as saying.
"It would be a great final if Barca and Madrid were to meet as the majority of the players also play for Spain's national team. It would be another huge step for Spanish football.
"Over the past decade or so we have seen a Spanish hegemony with teams like Valencia, Sevilla, Villarreal and Deportivo doing well, too."
Del Bosque won the Champions League twice as Madrid coach.