The match at the Parc des Princes is arguably the highlight of the first round of games in the group stage of the competition this season, although PSG will hope to avoid a repeat of the 2-1 defeat in this fixture that confirmed their exit from the competition in 2018.
The Ligue 1 champions are back at the top of the table after winning four of their first five games of the season, despite frequently struggling to hit top form so far.
Their last Champions League match in Paris, against Manchester United in their first knockout tie last season, saw them crash out in devastating style with an away goals defeat via a last-gasp penalty.
Here, Sports Mole looks at how PSG could line up as coach Thomas Tuchel tries to win with a squad weakened by injuries.
Tuchel has a severely depleted list of forward options in the absence of Neymar, who made his first appearance of the season at the weekend but is suspended for three games in Europe, and the injured pair of Kylian Mbappe and Edinson Cavani.
France livewire Mbappe is closing in on a comeback and has publicised his return to training but is not yet ready for the intensity of a Champions League match.
Neymar was booed by PSG fans in his first appearance of the season before scoring a late winner with an overhead kick, but he will be unable to continue that form due to an outburst in the aftermath of that defeat to United.
The temperamental Brazil striker frustratedly questioned the integrity of the referee following the painful result, leading to a three-match ban from the Champions League which he will start on Wednesday.
Eric Maxim Choupo-Moting, who has scored three times in a bright start to the season, is likely to take responsibility for leading the line.body check tags ::