The Royals are currently one point off the playoff places thanks to a recent run of form that has seen them take 10 points from a possible 18.
Their last victory came on Saturday with a comfortable 3-0 triumph at home to struggling Fulham.
Millwall head into the match on the same number of points as their opponents, though they were beaten 2-0 by Ipswich Town in their last outing.
Danny Guthrie could be in contention for Reading after spending much of the season on the sidelines, while Stephen Kelly, Hal Robson-Kanu and Nick Blackman are also understood to be nearing full fitness.
Possible starting lineups
Reading: Federici; Gunter, Obita, Hector, Pearce; Akpan, Norwood, Mackie, Taylor; Cox, Murray
Millwall: Forde; Edwards, Dunne, Beevers, Malone; Powell, Williams; Woolford, McDonald, Easter; Ranegie
Sports Mole says: 2-1