The visitors also have Costa Rican winger Joel Campbell, who joined the Athens club on loan from Arsenal, in attack to face PSG.
Swedish international striker Zlatan Ibrahimovic, who has scored seven goals in the group phase so far this season, will lead the line for Laurent Blanc's side.
Les Parisiens are currently on a run of 34 games without defeat in all competitions, but Olympiacos are also unbeaten since their loss in the return fixture back in September.
Paris Saint-Germain: Sirigu, Thiago Silva, Alex, Maxwell, Van der Wiel, Motta, Matuidi, Verratti, Cavani, Ibrahimovic, Lavezzi
Olympiacos: Roberto, Maniatis, Holebas, Manolas, Leandro Salino, Bong, Samaris, Fuster, Siovas, Campbell, Mitroglou