The Real Madrid forward has been struggling with both tendonitis and a thigh problem over the last two months, while his involvement in training has been sporadic.
However, it understood that the Ballon d'Or holder will feature from the onset on Monday as Portugal attempt to get their campaign off to a winning start.
Germany are currently on an 11-match unbeaten run in all competitions and breezed through their European qualification section for this summer's tournament, with nine wins and one draw leaving them eight points clear of second-placed Sweden.
It was Sweden that Portugal met in the playoffs after finishing second in their own qualification group, but Ronaldo inspired his side to an incredible 3-2 win in the second leg.
Portugal have also been on a strong run of form, however, with their last defeat occurring last September, when they were beaten 3-1 by Brazil in a friendly.
Meanwhile, the early indications are that Hugo Almeida will start as the centre forward.
Possible starting lineups
Germany: Neuer; Boateng, Mertesacker, Hummels, Howedes; Lahm, Kroos; Gotze, Ozil, Podolski; Muller
Portugal: Patricio; Pereira, Pepe, Alves, Coentrao; Meireles, Veloso, Moutinho; Nani, Almeida, Ronaldo
Sports Mole says: 1-1