The home side currently occupy fourth spot in the table having won one of their six matches in Group F, while they sit five points behind third-place Israel with four matches remaining.
Portugal, meanwhile, sit top of the group with 14 points, but they have played one game more than Russia, who sit two points adrift in second.
Northern Ireland will enter the match full of confidence after overcoming Russia last time out, while they also took a point from Portugal in the reverse match in October of last year.
Portugal, meanwhile, will once more be led by Cristiano Ronaldo. Former Manchester United teammate Nani should also start after recently returning from a long-term injury, while Helder Postiga is in line to win his 63rd cap.
N Ireland: DDDLW
N Ireland: Carroll; C Evans, J Evans, McAuley, Bruce; Davis, Brunt, Norwood, McGinn; Lafferty, Paterson
Portugal: Eduardo; Pereira, Alves, Pepe, Coentrao; Moutinho, Meireles, Veloso; Ronaldo, Postiga, Nani
Sports Mole says: 0-2