Palace held on for a goalless draw against Newcastle's Tyne-Wear rivals Sunderland last weekend to stay out of the Premier League relegation zone, but they remain only three points above safety.
The Eagles are winless in their last four games and have title contenders Chelsea next up, so Tony Pulis will be targeting a first top-flight away victory of 2014 to aid their battle to avoid the drop.
Danny Gabbidon and Barry Bannan face late fitness tests to decide whether they will be included in the squad, but Pulis will probably stick with the same starting XI that he named at the Stadium of Light.
In Remy's absence, Newcastle's likely deputy of Luuk de Jong or Papiss Cisse have only one Premier League goal between them this season, but will have Hatem Ben Arfa back to help ease the burden.
Santon has recovered from the knee injury that has kept him out of the club's last three matches, but has not trained all week because of tonsillitis. Midfielder Dan Gosling could be named in the home 18, despite being found guilty of breaching Football Association betting regulations this week.
Possible starting lineups
Newcastle: Krul; Yanga-Mbiwa, Williamson, Coloccini, Dummett; Sissoko, Anita, Tiote, Ben Arfa; De Jong, Gouffran