Going into that encounter, they have six points from a possible nine - the exact number as both Borussia Dortmund and Arsenal, who will meet in Germany on the same night.
Meanwhile, visiting Marseille could be without defender Rod Fanni because of an abductor problem.
The French side do not have a positive record from trips to Italy, having won just once in their eight visits.
Possible starting lineups
Napoli: Reina; Armero, Albiol, Fernandez, Uvini; Inler, Behrami; Hamsik, Callejon, Insigne; Higuain
Marseille: Mandanda; Morel, Abdallah, Diawara, N'Koulou; Cheyrou, Romao, Valbuena, Thauvin, A Ayew; Gignac
Sports Mole says: 2-0