The French outfit have picked up a point from their first two matches against Arsenal and Schalke 04, while Olympiakos have suffered back-to-back defeats to the same opposition.
The clash will be the first time Montpellier have faced Greek opposition, but Olympiakos have lost eight of their 12 matches in France.
Olympiakos, however, are on a seven-game winning win in their domestic league. That is in contrast to the home side who have won just two of their nine Ligue 1 matches this season.
Montpellier will be without Kairm Ait-Fana for the clash, while Garry Bocaly is suspended and will not take part. Olympiakos enter the match without Ariel Ibagaza, but Vasilis Torosidis should return to the side.
Montpellier: Pionnier; Jeunechamp, Congre, Hilton, Bedimo; Saihi, Stambouli; Camara, Belhanda, Cabella; Herrera
Olympiakos: Carroll; Torosidis, Manolas, Contreras, Holebas; Maniatis, Modesto; Abdoun, Fuster, Mitroglou; Djebbour
Sports Mole says: 1-1