Three places separate the two clubs going into the match, with Millwall two ahead of 18th-placed Wednesday, who themselves are just three above the drop zone.
The game is one of two that Millwall have in hand on the majority around them because of their FA Cup run, and manager Kenny Jackett's eye will surely be on the Wembley semi-final against Wigan Athletic on Saturday.
The two clubs last met on the second weekend of the season and that day it was Wednesday who edged a five-goal thriller 3-2 at Hillsborough.
Possible starting lineups
Millwall: Forde; Dunne, Shittu, Beevers, Lowry; St Ledger, Trotter, Chaplow; Keogh, Easter, Taylor
Wednesday: Kirkland, Buxton, Llera, Gardner, R Johnson, Holden, Coke, Olofinjana, Helan, J Johnson, Lita
Sports Mole says: 0-1