The former Northampton Town boss lost just twice in 12 games in temporary charge and will be hoping that his side can continue their impressive run at The Den.
Holloway could name an unchanged starting lineup as they look to overtake their opponents in the league table.
Sheffield Wednesday: WDWWDW
Possible starting lineups
Millwall: Forde; Fredericks, Malone, Shittu, Lowry, Keogh, Trotter, Bailey, Martin; Morison, McDonald
Sheffield Wednesday: Kirkland; Palmer, Mattock, Onyewu, Loovens; Semedo, Maguire, Lee, Maghoma, Helan; Lavery
Sports Mole says: 1-2