The Italian club's sporting director Beppe Marotta revealed on Wednesday evening that they had made contact with the Bulgarian, but it did not yield any positive result.
"It wasn't a refusal," he told Sky Sport Italia. "Berbatov prefers remaining in England due to family reasons.
"We contacted him after we knew he refused the Fiorentina move. I spoke with Manchester United's chief officer.
"We knew their decision to sell Berbatov and we started a normal move. We wanted to take advantage from this point. The aim is to improve ourselves."
Berbatov is now reportedly on course to sign for Fulham.